SUPPLEMENT

Introduction: : Mechanisms of Pulmonary Fibrosis

David Riches and G. Scott Worthen
Chest 120: 1S. [Full Text] [PDF]  

CD44 Is Required to Resolve Lung Inflammation

P. Teder and Paul W. Noble
Chest 120: 1S-2S. [Full Text] [PDF]  

Tumor Necrosis Factor Receptor Deficiency Protects Mice From Silica-Induced Lung Fibrosis by Altering Lung Matrix Metalloproteinase-13/Tissue Inhibitor of Metalloproteinase-1 RNA Expression and Decreasing Activating Protein-1 Activation

Luis A. Ortiz, Joseph A. Lasky, Evelyn Gozal, Arnold R. Brody, Annie Pardo, Moises Selman, Victor Ruiz, and Mitchell Friedman
Chest 120: 2S-3S. [Full Text] [PDF]  

Elevated Levels of Monocyte Chemoattractant Protein-1 Are Associated With Bronchiolitis Obliterans Syndrome, a Fibrotic Disease of the Small Airways

John A. Belperio, M. P. Keane, M. D. Burdick, J. P. Lynch, III, Y. Y. Xue, S. L. Kuntel, and R. M. Strieter
Chest 120: 2S. [Full Text] [PDF]  

Transforming Growth Factor-ß₁ Secretion From Murine Macrophages Is Released by In Vivo Ingestion of Apoptotic Cells

Mai-Lan N. Huynh, Valerie A. Fadok, and Peter M. Henson
Chest 120: 3S. [Full Text] [PDF]  

Prevention of Lung Fibrosis in a Rabbit Model of Bleomycin-Induced Lung Fibrosis Upon Aerosol Application of Heparin or Urokinase

Andreas Günther, Norbert Lübke, Clemens Ruppert, Norbert Weissman, Friedrich Grimminger, and Werner Seeger
Chest 120: 4S-5S. [Full Text] [PDF]  

Fluorescein Isothiocyanate-Induced Pulmonary Fibrosis Is Regulated by Monocyte Chemoattractant Protein-1 and Chemokine Receptor 2

Bethany B. Moore, Paul J. Christensen, Carol Wilke, Stephanie Sitterding, Robert Paine, III, and Galen B. Toews
Chest 120: 4S. [Full Text] [PDF]  

Type 1/Type 2 Cytokine Paradigm and the Progression of Pulmonary Fibrosis

Nicholas W. Lukacs, Cory Hogaboam, Stephen W. Chensue, Kate Blease, and Steven L. Kunkel
Chest 120: 5S-8S. [Abstract] [Full Text] [PDF]  

Interleukin-12 Attenuates Pulmonary Fibrosis via Induction of Interferon-

Michael P. Keane, John A. Belperio, Marie D. Burdick, and Robert M. Strieter
Chest 120: 8S. [Full Text] [PDF]  

Bleomycin-Induced Pulmonary Fibrosis Is Attenuated in Interferon- Knockout Mice

Edward S. Chen, Brian M. Greenlee, Marsha Wills-Karp, and David R. Moller
Chest 120: 8S. [Full Text] [PDF]  

Inflammatory Cell Infiltrate and Pulmonary Fibrosis in Mice Overexpressing Endothelin-1

Karen A. Fagan, B. Hocher, C. Schwarz, K. Thone-Reineke, K. El-Hag, S. Elitok, C. Bauer, H. Neumayer, D. M. Rodman, and F. Theuring
Chest 120: 9S-10S. [Full Text] [PDF]  

Regulation of CCAAT/Enhancer-Binding Protein-ß Is Altered in Primary Lung Fibroblasts Obtained From Patients With Idiopathic Pulmonary Fibrosis

Roberto A. Cruz-Gervis, Arlene A. Stecenko, Timothy S. Blackwell, Linda Sealy, James E. Loyd, Gayle King, and Kenneth L. Brigham
Chest 120: 9S. [Full Text] [PDF]  

Mice Overexpressing Extracellular Superoxide Dismutase Are Resistant to Bleomycin-Induced Pulmonary Injury

Russell P. Bowler, M. Nicks, and J. D. Crapo
Chest 120: 10S. [Full Text] [PDF]  

Bleomycin Lung Injury in Interleukin-12 Knockout Mice

Richard L. Kradin, Hideo Sakamoto, Long Hai Zhao, and Carol Leary
Chest 120: 10S-11S. [Full Text] [PDF]  

Alveolar Epithelial Cell Chemokine Expression Induced by Specific Antiviral CD8+ T-Cell Recognition Plays a Critical Role in the Perpetuation of Experimental Interstitial Pneumonia

Min Q. Zhao, Maura P. Foley, Mark H. Stoler, and Richard I. Enelow
Chest 120: 11S-13S. [Full Text] [PDF]  

Effect of Nitric Oxide Donors on Human Lung Fibroblast Proliferation In Vitro

Xiangder Liu, Yunkui K. Zhu, Hangjun Wang, Tadashi Kohyama, Fuqiang Wen, and Stephen I. Rennard
Chest 120: 13S-14S. [Full Text] [PDF]  

Phosphodiesterase Inhibitor Attenuation of Fibroblast Chemotaxis Depends on Endogenous Prostaglandin Production

Tadashi Kohyama, Xiangder Liu, Yunkui Zhu, Fu-Qiang Wen, Hangjun Wang, and Stephen I. Rennard
Chest 120: 14S-15S. [Full Text] [PDF]  

Interleukin-13, a Mediator of Subepithelial Fibrosis, Enhances Growth Factor Production and Proliferation in Human Airway Epithelial Cells

Brian Booth, James Bonner, Nancy Akley, Mariangela Macchione, Kenneth Adler, and Linda D. Martin
Chest 120: 15S. [Full Text] [PDF]  

Monocytes May Regulate Tissue Fibrosis : Role of Reactive Oxygen Species in Monocyte Survival and in the Activation of Latent Transforming Growth Factor-ß

Clay B. Marsh, Todd W. Kelley, Mandy M. Graham, Chunming Dong, and Pascal J. Goldschmidt-Clermont
Chest 120: 15S-16S. [Full Text] [PDF]  

Inducible Expression of Tumor Necrosis Factor- in Transgenic Mouse Lung

Brian R. Vuillemenot and Gary W. Hoyle
Chest 120: 16S. [Full Text] [PDF]  

Extracellular Matrix Modulates Expression of Connexin Messenger RNA and Protein by Alveolar Epithelial Cells

Yihe Guo, Andrea I. Alford, Cara Martinez-Williams, and D. Eugene Rannels
Chest 120: 17S-19S. [Full Text] [PDF]  

Protein Kinases and Cytoskeletal Integrity Modulate the Expression of Fibronectin by Affecting Cyclic Adenosine Monophosphate Response Binding Element

Jesse Roman
Chest 120: 19S-20S. [Full Text] [PDF]  

Increasing Surface Iron Increases Asbestos-Induced Expression of Procollagen and Transforms Nonfibrogenic Titanium Dioxide Into a Fibrogenic Dust : Role of NF-B

A. Churg, J. Dai, and J. L. Wright
Chest 120: 19S. [Full Text] [PDF]  

Eosinophil-Fibroblast Interactions in Fibrogenesis : Eosinophils Induce Fibroblast Secretion of Interleukin–6 and Expression of Genes Involved in Extracellular Matrix Homeostasis

Sameer K. Mathur, Bruce M. Espenshade, John Varga, and Steven J. Ackerman
Chest 120: 20S. [Full Text] [PDF]  

Fourteen-Membered Ring Macrolides Inhibit Vascular Cell Adhesion Molecule-1 Messenger RNA Induction Preventing Neutrophil-Induced Lung Injury and Fibrosis in Bleomycin-Challenged Mice

Arata Azuma, Yingji Li, Jiro Usuki, Akinori Aoyama, Ttsuji Enomoto, and Shoji Kudoh
Chest 120: 20S-22S. [Full Text] [PDF]  

Transgenic Mouse Models To Determine the Role of Epidermal Growth Factor Receptor in Epithelial Cell Proliferation, Apoptosis, and Asbestosis

Cynthia Timblin, Raymond Robledo, Mercedes Rincon, Andrew Cummins, Linda Pfeiffer, and Brooke Mossman
Chest 120: 22S-24S. [Full Text] [PDF]  

Use of Transgenic Luciferase Reporter Mice To Determine Activation of Transcription Factors and Gene Expression by Fibrogenic Particles

Andrea K. Hubbard, Cynthia R. Timblin, Mercedes Rincon, and Brooke T. Mossman
Chest 120: 24S-25S. [Full Text] [PDF]  

Homozygous C1qa Deficiency Alters Pulmonary Clearance of Apoptotic Cells

R. William Vandiver, M. Botto, P. L. Taylor, C. A. Ogden, V. A. Fadok, M. J. Walport, and P. M. Henson
Chest 120: 25S-26S. [Full Text] [PDF]  

Tyrosine Nitration and Mitogen-Activated Protein Kinase Activation in Asbestosis-Induced Pulmonary Fibrosis

Elliott Kagan, Akitaka Iwagaki, Nonghoon Choe, Ping Zhang, Yi-Zhe Wang, and James C. Bonner
Chest 120: 26S-27S. [Full Text] [PDF]  

Transgenic Models for Study of Lung Morphogenesis and Repair : Parker B. Francis Lecture

Jeffrey A. Whitsett, Stephan W. Glasser, Jay W. Tichelaar, Anne-Karina T. Perl, Jean C. Clark, and Susan E. Wert
Chest 120: 27S-30S. [Full Text] [PDF]  

Rat Alveolar Type II Cells Inhibit Fibroblast Proliferation by Secreting Interleukin-1 That Stimulates Prostaglandin E₂ Production by Fibroblasts

Tianli Pan, John M. Shannon, Jay Y. Westcott, and Robert J. Mason
Chest 120: 30S. [Full Text] [PDF]  

Epimorphin in Bleomycin-Induced Pulmonary Fibrosis in Mice

Yasuhiro Terasaki
Chest 120: 30S-32S. [Full Text] [PDF]  

H₂O₂ Production by Myofibroblasts Is Dependent on Src Kinase(s) and Actin Cytoskeletal Regulation

Victor J. Thannickal, Jose M. Larios, and Barry L. Fanburg
Chest 120: 32S-33S. [Full Text] [PDF]  

Enhancement of Fibrogenesis by the p53 Tumor Suppressor Protein in Asbestos-Exposed Rodents

Anne Nelson, Tamra Mendoza, Gary W. Hoyle, Arnold R. Brody, Cesar Fermin, and Gilbert F. Morris
Chest 120: 33S-34S. [Full Text] [PDF]  

Gelatinase B Is Required for Alveolar Bronchiolization After Intratracheal Bleomycin Instillation

Tomoko Betsuyaku, Yuh Fukuda, William C. Parks, J. Michael Shipley, and Robert M. Senior
Chest 120: 34S. [Full Text] [PDF]  

Evidence That Neutrophil Elastase-Deficient Mice Are Resistant to Bleomycin-Induced Fibrosis

Sarah E. Dunsmore, Jurgen Roes, Felix J. Chua, Anthony W. Segal, Steven E. Mutsaers, and Geoffrey J. Laurent
Chest 120: 35S-36S. [Full Text] [PDF]  

Matrilysin in Epithelial Repair and Defense

William C. Parks, Yolanda S. López-Boado, and Carole L. Wilson
Chest 120: 36S-41S. [Abstract] [Full Text] [PDF]  

Mechanism of Structural Remodeling in Pulmonary Fibrosis

Yuh Fukuda, Hiroshi Mochimaru, Yasuhiro Terasaki, Masashi Kawamoto, and Shoji Kudoh
Chest 120: 41S-43S. [Full Text] [PDF]  

Is Smad3 a Major Player in Signal Transduction Pathways Leading to Fibrogenesis?

Anita B. Roberts, Ester Piek, Erwin P. Böttinger, Gillian Ashcroft, James B. Mitchell, and Kathleen C. Flanders
Chest 120: 43S-47S. [Abstract] [Full Text] [PDF]  

Gelatinolytic Activity in the BAL Fluid of Patients With Sarcoidosis

Jesse Roman, Howard Silverboard, Rafael L. Perez, and Samuel M. Aguayo
Chest 120: 43S. [Full Text] [PDF]  

Expression of Transforming Growth Factor-ß Induces Fibroproliferative Pulmonary Disease in Fibrosis-Resistant Mice

Arnold R. Brody, G. Sakuntala Warshamana, Jing-Yao, and Derek A. Pociask
Chest 120: 48S-49S. [Full Text] [PDF]  

Biological Effects of Transforming Growth Factor-ß₁ in Idiopathic Pulmonary Fibrosis May Be Regulated by the Activation of Latent Transforming Growth Factor-ß₁ and the Differential Expression of Transforming Growth Factor-ß Receptors

Nasreen Khalil, Robert O’Connor, Leslie I. Gold, Trilok Parekh, and Ganesh Raghu
Chest 120: 48S. [Full Text] [PDF]  

Integrin-Mediated Activation of Transforming Growth Factor-ß₁ in Pulmonary Fibrosis

Dean Sheppard
Chest 120: 49S-53S. [Abstract] [Full Text] [PDF]  

Fibroblasts as Sentinel Cells : Role of the CD40-CD40 Ligand System in Fibroblast Activation and Lung Inflammation and Fibrosis

Julia Kaufman, Beth A. Graf, Edmund C. Leung, Stephen J. Pollock, Laura Koumas, Sireesha Y. Reddy, Timothy M. Blieden, Terry J. Smith, and Richard P. Phipps
Chest 120: 53S-55S. [Full Text] [PDF]  

Role of Receptor Tyrosine Kinases and Mitogen-Activated Protein Kinases in Metal-Induced Pulmonary Fibrosis

James C. Bonner, Yi-Zhe Wang, Ping Zhang, Annette Rice, Limin Zhang, Kenneth Adler, Nonghoon Choe, and Elliott Kagan
Chest 120: 55S-56S. [Full Text] [PDF]  

Idiopathic Pulmonary Fibrosis Can Be an Autosomal Dominant Trait in Some Families

Annis Marney, Kirk B. Lane, John A. Phillips, III, David J. Riley, and James E. Loyd
Chest 120: 56S. [Full Text] [PDF]  

Is Vasculitis an Early Pathogenic Mechanism of Interstitial Pulmonary Fibrosis?

Angela M. Davis, Joyce E. Johnson, Roberto Cruz-Gervis, Annis Marney, Yi Wei Tang, James E. Loyd, and R. Stokes Peebles
Chest 120: 57S. [Full Text] [PDF]  

Region-Specific Quantitation of Elastin in Fibrotic Mouse

Barry Starcher and C. Kuhn
Chest 120: 57S-58S. [Full Text] [PDF]  

Role of Human Leukocyte Antigen-DP in the Presentation of Beryllium to T Cells in Chronic Beryllium Disease

Andrew P. Fontenot, Michaelann Vollmer, Lee S. Newman, and Brian L. Kotzin
Chest 120: 58S. [Full Text] [PDF]  

Reactive Nitrogen Species, Airway Inflammation, and Fibrosis in Lung Transplant

Joao A. deAndrade, John Crow, Liliana Viera, C. Bruce Alexander, K. Randall Young, David McGiffin, George Zorn, Sadis Matalon, and Robert Jackson
Chest 120: 58S-59S. [Full Text] [PDF]  

Biphasic Remodeling of Alveolar Capillaries in Idiopathic Pulmonary Fibrosis

Masahito Ebina, Minoru Shimizugawa, Takashi Suzuki, Shigefumi Fujimura, Tohru Takahashi, Masahiro Kohzuki, and Toshihiro Nukiwa
Chest 120: 59S-60S. [Full Text] [PDF]  

Effect of Hepatocyte Growth Factor on Lung Injury and Development of Clinical Application

Kenichi Akiyama, M. Miki, K. Narumi, M. Ebina, M. Yaekashiwa, A. Nakamura, T. Nakamura, and T. Nukiwa
Chest 120: 59S. [Full Text] [PDF]  

Transforming Growth Factor-ß₁ Modifies Fibroblast Growth Factor-2 Production in Type II Cells

Cheng-Ming Li, Jody Khosla, Paul Hoyle, and Philip L. Sannes
Chest 120: 60S-61S. [Abstract] [Full Text] [PDF]  

Platelet-Derived Growth Factor Receptors Are Essential in the Development of Asbestos-Induced Fibrosis

Joseph A. Lasky, Mitchell Friedman, Ying Zhuo, Jing-Yao Liu, Halet Poovey, and Arnold Brody
Chest 120: 61S. [Full Text] [PDF]  

A Sense Oligodeoxynucleotide as a Novel Nonsteroidal Antifibrotic Drug : Comparison to Glucocorticoids

Kenneth Cutroneo
Chest 120: 62S. [Full Text] [PDF]  

Idiopathic Pulmonary Fibrosis : Survival as a Function of Oxygen Therapy and Treatment Program

William W. Douglas, Jay H. Ryu, and Darrell R. Schroeder
Chest 120: 62S. [Full Text] [PDF]  

Role of c-Jun N-Terminal Kinase in Radiation-Induced Lung Fibrosis

Soo-taek Uh, Do Jin Kim, Seung Hyuk Moon, Yong Hoon Kim, Uk Seok Kim, Doo Ho Choi, and Choon Sik Park
Chest 120: 63S-64S. [Full Text] [PDF]  

Differential Expression, Surface Binding, and Response to Connective Tissue Growth Factor in Lung Fibroblast Subpopulations

James S. Hagood, Joseph A. Lasky, James E. Nesbitt, and Patricia Segarini
Chest 120: 64S-66S. [Full Text] [PDF]  

T-Cell Activation in the Lungs of Patients With Systemic Sclerosis and Its Relation With Pulmonary Fibrosis

Paul Bresser, Henk M. Jansen, Frank R. Weller, René Lutter, and Theo A. Out
Chest 120: 66S-68S. [Full Text] [PDF]  

Circulating Transforming Growth Factor-ß₁ : A Potential Marker of Disease Activity During Idiopathic Pulmonary Fibrosis

Suk-Joong Yong, Arun Adlakha, and Andrew H. Limper
Chest 120: 68S-70S. [Full Text] [PDF]  

Tissue Localization of Transforming Growth Factor-ß₁ in Nonspecific Interstitial Pneumonitis Compared with Usual Interstitial Pneumonitis

Arthur D. Andrews, Jay H. Ryu, and Andrew H. Limper
Chest 120: 70S-71S. [Full Text] [PDF]  

Influence of Hyperglycemia to the Severity of Pulmonary Fibrosis

Jiro Usuki, Tatsuji Enomoto, Arata Azuma, Kuniko Matsuda, Akinori Aoyama, and Shoji Kudoh
Chest 120: 71S. [Full Text] [PDF]  

Does Reduced ₁-Antitrypsin Activity Explain the Link Between Cigarette Smoking and Idiopathic Pulmonary Fibrosis?

Edward D. Chan, Annemarie H. Ralston, and Leland Shapiro
Chest 120: 72S-74S. [Full Text] [PDF]  

Serum Concentrations of Surfactant Proteins A and D Predict Mortality in Patients With Idiopathic Pulmonary Fibrosis

Kelly E. Greene, Y. Kuroki, B. Bucher Bartelson, T. E. King, G. W. Hunninghake, P. E. Parsons, L. S. Newman, H. Nagoe, R. Tudor, C. Kuhn, and R. J. Mason
Chest 120: 72S. [Full Text] [PDF]  

Hypoxia Induces Non-Ligand–Dependent Activation of Mitogen-Activated Protein Kinases in Pulmonary Artery Adventitial Fibroblasts : Role in Proliferation and Apoptosis

Mita Das, Marla Moore, Raphael Nemenoff, and Kurt R. Stenmark
Chest 120: 74S. [Full Text] [PDF]  

Increased Detection of Herpesvirus DNA in Idiopathic Pulmonary Fibrosis

Yi-Wei Tang, Joyce Johnson, Roberto Cruz-Gervis, Barney Graham, Kenneth Brigham, John Oates, James Loyd, and Arlene Stecenko
Chest 120: 74S-75S. [Full Text] [PDF]  

Familial Interstitial Pulmonary Fibrosis and Linkage to Chromosome 14

Kirk B. Lane, A. Marney, J. A. Phillips, III, E. Loyd, R. Gaddipati, and J. Loyd
Chest 120: 75S-76S. [Full Text] [PDF]  

Prognostic Value of Fibroblastic Foci in Patients With Usual Interstitial Pneumonia

Kevin R. Flaherty, Thomas V. Colby, William D. Travis, Galen B. Toews, Andrew Flint, Robert L. Strawderman, III, Arvind Jain, Joseph P. Lynch, III, and Fernando J. Martinez
Chest 120: 76S-77S. [Full Text] [PDF]  

Extracellular Matrix Remodeling in Idiopathic Pulmonary Fibrosis

Annie Pardo and Moisés Selman
Chest 120: 77S. [Full Text] [PDF]  

Mechanisms of Pulmonary Fibrosis : Conference Summary

Robert M. Strieter
Chest 120: 77S-85S. [Full Text] [PDF]  

Conference Sponsors

Chest 120: 86S. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.