SUPPLEMENT

Introduction: Acute Lung Injury

Edward Abraham and Lance Terada
Chest 116: 1S. [Full Text] [PDF]  

41st Aspen Lung Conference: Overview

Thomas L. Petty
Chest 116: 1S-2S. [Full Text]  

Lung Cytokines and ARDS: Roger S. Mitchell Lecture

Thomas R. Martin
Chest 116: 2S-8S. [Full Text]  

Targeted Lung Expression of Interleukin-11 Enhances Murine Tolerance of 100% Oxygen and Diminishes Hyperoxia-Induced DNA Fragmentation

A. B. Waxman, O. Einarsson, T. Seres, R. G. Knickelbein, R. Homer, J. B. Warshaw, R. Johnston, and J. A. Elias
Chest 116: 8S-9S. [Full Text]  

Anti-IL-8 Autoantibodies in Alveolar Fluid From Patients at Risk for ARDS and With Well-defined ARDS

A. Kurdowska, J.M. Noble, K.P. Steinberg, J. Ruzinski, L.D. Hudson, and T.R. Martin
Chest 116: 9S. [Full Text]  

Lung Injury Caused by Mechanical Ventilation

Arthur S. Slutsky
Chest 116: 9S-15S. [Full Text]  

Independent and Combined Effects of Inhaled Nitric Oxide, Liquid Perfluorochemical, and High-Frequency Oscillatory Ventilation in Premature Lambs With Respiratory Distress Syndrome

John P. Kinsella, Thomas A. Parker, Henry Galan, Brett C. Sheridan, and Steven H. Abman
Chest 116: 15S-16S. [Full Text]  

Optimal Positive End-Expiratory Pressure Fails to Preserve Nonrespiratory Lung Function in Acute Lung Injury

K. Creamer, L. McCloud, L. Fisher, and I. Ehrhart
Chest 116: 16S-17S. [Full Text]  

Hyaluronan Fragments Induce Plasminogen Activator Inhibitor-1 and Inhibit Urokinase Activity in Mouse Alveolar Macrophages: A Potential Mechanism for Impaired Fibrinolytic Activity in Acute Lung Injury

M. R. Horton, M. A. Olman, and P. W. Noble
Chest 116: 17S. [Full Text]  

Gelatinase B Deficiency Does Not Protect Against Lipopolysaccharide-Induced Acute Lung Injury

Tomoko Betsuyaku, J. Michael Shipley, Zhi Liu, and Robert M. Senior
Chest 116: 17S-18S. [Full Text]  

Endothelial Activation in ARDS

Guy A. Zimmerman, Kurt H. Albertine, Holly J. Carveth, Edward A. Gill, Colin K. Grissom, John R. Hoidal, Tada-atsu Imaizumi, Christopher G. Maloney, Thomas M. McIntyre, John R. Michael, James F. Orme, Stephen M. Prescott, and Matthew S. Topham
Chest 116: 18S-24S. [Full Text]  

Adenoviral-Mediated Overexpression of the NA,K-ATPase ß₁ Subunit Gene Increases Lung Edema Clearance and Improves Survival During Acute Hyperoxic Lung Injury in Rats

Phillip Factor, Vidas Dumasius, Fernado Saldias, and Jacob I. Sznajder
Chest 116: 24S-25S. [Full Text]  

Activation of Endothelial NADPH Oxidase as the Source of a Reactive Oxygen Species in Lung Ischemia

A. B. Fisher, A. B. Al-Mehdi, and V. Muzykantov
Chest 116: 25S-26S. [Full Text]  

Interleukin-6 Protection in Hyperoxic Lung Injury

Nicholas S. Ward, A.B. Waxman, O. Einarsson, and J.A. Elias
Chest 116: 26S. [Full Text]  

Closing Pressure Rather Than Opening Pressure Determines Optimal Positive End-Expiratory Pressure and Avoids Overdistention

Kevin M. Creamer, Laryssa L. McCloud, Lyle E. Fisher, and Ina C. Ehrhart
Chest 116: 26S-27S. [Full Text]  

A Murine Model of Volutrauma: Potential Contribution of Inflammatory Cell Proteases to Lung Injury

T. Gronski, Jr., E. Lum, J. Campbell, and S. D. Shapiro
Chest 116: 28S. [Full Text]  

Effect of Positive End-Expiratory Pressure on Regional Lung Expansion of Oleic Acid-Injured Dogs

M. A. Martynowicz, T. A. Minor, T. A. Wilson, B. J. Walters, and R. D. Hubmayr
Chest 116: 28S-29S. [Full Text]  

Ventilator-Associated Lung Injury Decreases Lung Ability To Clear Edema and Downregulates Alveolar Epithelial Cell Na,K-Adenosine Triphosphatase Function

E. Lecuona, F. Saldías, A. Comellas, K. Ridge, C. Guerrero, and J. I. Sznajder
Chest 116: 29S-30S. [Full Text]  

Increasing Airway Pressures Can Promote Transvascular Edema Reabsorption

R.M. Effros, E.R. Jacobs, R.M. Schapira, W. Lin, and K. Presberg
Chest 116: 30S-31S. [Full Text]  

Interstitial Pressure and Proteoglycan Degradation in Hydraulic- and Elastase-Induced Lung Edema

G. Miserocchi, A. Passi, R. Albertini, D. Negrini, and G. De Luca
Chest 116: 31S. [Full Text]  

Macrophage Elastase Prevents Gemella morbillorum Infection and Improves Outcome Following Murine Bone Marrow Transplantation

W. Hartzell and S. D. Shapiro
Chest 116: 31S-32S. [Full Text]  

Differential Regulation of Vascular Endothelial Growth Factor During Ventilated Pulmonary Ischemia

Aimee Yu, A. Alcasabas, G. Semenza, and P. Becker
Chest 116: 32S. [Full Text]  

Regulation of Pulmonary Microvascular Endothelial Cell Cyclic Adenosine Monophosphate by Adenylyl Cyclase: Implications for Endothelial Barrier Function

Troy Stevens and W.J. Thompson
Chest 116: 32S-33S. [Full Text]  

Cyclic Adenosine Monophosphate Protects Endothelial Barrier Function Independent of Inhibiting 20-kd Myosin Light Chain-Dependent Tension Development

Alan B. Moy, James E. Bodmer, Ken Blackwell, Sandy Shasby, Anant Kamath, and D. Michael Shasby
Chest 116: 33S. [Full Text]  

Reversal of Ischemia/Reperfusion Lung Injury by Inhibition of Polymorphonuclear Leukocytes

Joseph W. Barnard, K. Shappell, and M. Yoshitake
Chest 116: 33S-34S. [Full Text]  

Pentoxifylline Markedly Reduces Pulmonary Neutrophil Sequestration

I. Ehrhart, L. McCloud, K.M. Creamer, and H. Ocasio
Chest 116: 34S. [Full Text]  

Neutrophil-Derived Heparin-binding Protein: A Monocyte-Specific Chemoattractant That Induces Monocyte Migration into Rabbit Lungs In Vivo

Dennis E. Doherty, J. Nakano, and K. Nakano
Chest 116: 34S-35S. [Full Text]  

Regulation of Gap Junction Proteins by Alveolar Epithelial Cells in Response to Injury

V. Abraham, K. DeBolt, R. Savani, and Michael Koval
Chest 116: 35S. [Full Text]  

HTI56, An Integral Apical Membrane Protein of the Human Alveolar Type I Cell, Is a Biochemical Marker of Acute Lung Injury

V. Newman, R. Gonzalez, M. Matthay, and L. Dobbs
Chest 116: 35S-36S. [Full Text]  

Alloreactive Th1 Cells Localize in Lung and Induce Acute Lung Injury

Anne E. Dixon, J. B. Mandac, P. J. Martin, D. K. Madtes, R. C. Hackman, and J. G. Clark
Chest 116: 36S-37S. [Full Text]  

Activated Alveolar Macrophage-Derived Nitric Oxide Predicts the Development of Lung Damage After Marrow Transplantation in Mice

Imad Y. Haddad, D.H. Ingbar, A. Panoskaltsis-Mortari, and B.R. Blazar
Chest 116: 37S. [Full Text]  

Adhesion Molecules and Cellular Biomechanical Changes in Acute Lung Injury: Giles F. Filley Lecture

Claire M. Doerschuk, Joseph P. Mizgerd, Hiroshi Kubo, Lan Qin, and Toshio Kumasaka
Chest 116: 37S-43S. [Full Text]  

Polymorphonuclear Leukocytes Released From the Bone Marrow and Acute Lung Injury

Stephan F. van Eeden, Yuko Kitagawa, Yukio Sato, and James C. Hogg
Chest 116: 43S-46S. [Full Text]  

Complement Inhibition Attenuates Human Lung Transplant Reperfusion Injury: A Multicenter Trial

Martin R. Zamora, R. D. Davis, S. H. Keshavjee, L. Schulman, J. Levin, U. Ryan, and G. A. Patterson
Chest 116: 46S. [Full Text]  

Regulation of Neutrophil Activation in Acute Lung Injury

Gregory P. Downey, Qin Dong, Joshua Kruger, Shoukat Dedhar, and Vera Cherapanov
Chest 116: 46S-54S. [Full Text]  

An Intracellular Signaling Pathway Linking Lipopolysaccharide Stimulation to Cellular Responses of the Human Neutrophil: The p38 MAP Kinase Cascade and its Functional Significance

Jerry A. Nick, Natalie J. Avdi, Scott K. Young, Patrick P. McDonald, Marcella A. Billstrom, Peter M. Henson, Gary L. Johnson, and G. Scott Worthen
Chest 116: 54S-55S. [Full Text]  

Ischemia-Reperfusion Lung Injury Is Prevented by Apocynin, a Novel Inhibitor of Leukocyte NADPH Oxidase

David B. Pearse and Jeffrey M. Dodd-o
Chest 116: 55S-56S. [Full Text]  

Regulation of Oxidant Production in Acute Lung Injury

Karl A. Sanders, T. Huecksteadt, P. Xu, A. B. Sturrock, and John R. Hoidal
Chest 116: 56S-61S. [Full Text]  

Surfactant Protein C Promoter-Driven Expression of T1-Alpha Induces Lung Inflammation

C.E. Girod, D.H. Shin, M.W. Geraci, H.B. Warren, L.G. Dobbs, B. Gao, J.S. Rainer, A.K. Bauer, M. Ikegami, J.M. Shannon, and Y.E. Miller
Chest 116: 61S. [Full Text]  

Protective Effects of Heme Oxygenase-1 in Acute Lung Injury

Leo E. Otterbein, Patty J. Lee, Beek Yoke Chin, Irina Petrache, Sharon L. Camhi, Jawed Alam, and Augustine M. K. Choi
Chest 116: 61S-63S. [Full Text]  

Pathways to Cell Death in Hyperoxia

Stuart Horowitz
Chest 116: 64S-67S. [Full Text] [PDF]  

Neutrophil Apoptosis in the Lung After Hemorrhage or Endotoxemia: Apoptosis and Migration Are Independent of Interleukin-1ß

Merdad V. Parsey, D. Kaneko, R. Shenkar, and E. Abraham
Chest 116: 67S-68S. [Full Text]  

Growth Factor Control of Type II Cell Apoptosis

Randolph H. Hastings, D. Summers-Torres, D. Burton, and L. Deftos
Chest 116: 68S-69S. [Full Text]  

Signal Transduction by Tumor Necrosis Factor: The Parker B. Francis Lectureship

David V. Goeddel
Chest 116: 69S-73S. [Full Text]  

Use of Genetically Altered Mice to Investigate the Role of Nuclear Factor-Kappa B Activation and Cytokine Gene Expression in Sepsis-Induced ARDS

Timothy S. Blackwell, F.E. Yull, C.-L. Chen, A. Venkatakrishnan, T.R. Blackwell, D.J. Hicks, L.H. Lancaster, J.W. Christman, and L.D. Kerr
Chest 116: 73S-74S. [Full Text]  

Posttranscriptional Regulation of Lung Elastin Expression Involves Binding of a Developmentally Regulated Cytosolic Protein to an Open-Reading Frame cis-Element in the Messenger RNA

Mancong Zhang and William C. Parks
Chest 116: 74S. [Full Text]  

Epidemiology of Acute Lung Injury and ARDS

Leonard D. Hudson and Kenneth P. Steinberg
Chest 116: 74S-82S. [Full Text]  

Ethanol Ingestion Impairs Alveolar Epithelial Glutathione Homeostasis and Function, and Predisposes to Endotoxin-Mediated Acute Lung Injury

David Guidot, M. Moss, F. Holguin, M. Lois, and L. Brown
Chest 116: 82S. [Full Text]  

Elevated Pulmonary Edema Fluid Concentrations of Soluble Intercellular Adhesion Molecule-1 in Patients With Acute Lung Injury: Biological and Clinical Significance

Edward R. Conner, Lorraine B. Ware, Gunnard Modin, and Michael A. Matthay
Chest 116: 83S-85S. [Full Text]  

Surfactant Lavage Treatment in a Model of Respiratory Distress Syndrome

Charles G. Cochrane and Susan D. Revak
Chest 116: 85S-87S. [Full Text]  

Hyperoxia Upregulated Na,K-Adenosine Triphosphatase ß₁ Gene Transcription

Christine H. Wendt, Renuka Sharma, Howard Towle, Gregory Gick, and David H. Ingbar
Chest 116: 87S-88S. [Full Text]  

Dopamine Regulates NA,K-Adenosine Triphosphatase in Alveolar Epithelial Cells via the Mitogen-Activated Protein Kinase/Extracellular-Signal-Regulated Kinase Pathway

C. Guerrero, A. Ghosh, E. Lecuona, K. Ridge, E. Santos, and J.I. Sznajder
Chest 116: 88S-89S. [Full Text]  

Stretch-Induced Mitogen-Activated Protein Kinase Activation and Interleukin-8 Production in Type II Alveolar Cells

D. Quinn, A. Tager, P. M. Joseph, J. V. Bonventre, T. Force, and C. A. Hales
Chest 116: 89S-90S. [Full Text]  

T-Cell Chemokines Interferon-Inducible Protein-10 and Monokine Induced by Interferon-Gamma Are Upregulated in Bleomycin-Induced Lung Injury

A. Tager, A. Luster, and Richard Kradin
Chest 116: 90S. [Full Text]  

Serum Surfactant Protein-A Levels Predict Development of ARDS in At-Risk Patients

K.E. Greene, S. Ye, R.J. Mason, and P.E. Parsons
Chest 116: 90S-91S. [Full Text]  

Systematic Evaluation of the Mitogen-Activated Protein Kinases in the Induction of iNOS by Tumor Necrosis Factor-Alpha and Interferon-Gamma

E. D. Chan, B. W. Winston, S. T. Uh, L. K. Remigio, and D. W. H. Riches
Chest 116: 91S-92S. [Full Text]  

Transgenic HbS Mouse Neutrophils in Increased Susceptibility to Acute Lung Injury: Implications for Sickle Acute Chest Syndrome

L. Hsu, T. McDermott, L. Brown, and S. M. Aguayo
Chest 116: 92S-93S. [Full Text]  

CXC Chemokines Regulate Angiogenic Activity in Acute Lung Injury

Michael P. Keane, Carol A. Wilke, Marie D. Burdick, Susan B. Morris, Mary C. Glass, and Robert M. Strieter
Chest 116: 93S-94S. [Full Text]  

Hepatocyte Growth Factor Stimulates Migration of Type II Alveolar Epithelial Cells on the Provisional Matrix Proteins Fibronectin and Fibrinogen

H.J. Kim, P.J. Sammak, and D.H. Ingbar
Chest 116: 94S-95S. [Full Text]  

Mechanical Ventilation of Various Human Lung Cells In Vitro: Identification of the Macrophage as the Main Producer of Inflammatory Mediators

Irène Dunn and Jérôme Pugin
Chest 116: 95S-97S. [Full Text]  

Reduced Growth Factor Expression in Mice Resistant to Developing Fibroproliferative Lesions After Lung Injury

Arnold R. Brody, G. Hoyle, J.-Y. Liu, and D. Brass
Chest 116: 97S. [Full Text]  

The Effect of Chronic Alcohol Abuse on the Incidence of ARDS and the Severity of the Multiple Organ Dysfunction Syndrome in Adults with Septic Shock: An Interim and Multivariate Analysis

Marc Moss, K.P. Steinberg, D.M. Guidot, G.F. Duhon, P. Treece, R. Wolken, L.D. Hudson, and P.E. Parsons
Chest 116: 97S-98S. [Full Text]  

The Heterogeneity of BAL Cells and Protein in Patients at Risk for and With ARDS

Kenneth P. Steinberg, J. Ruzinski, E. Caldwell, F. Radella, II, D. Davis, P. Treece, L. Hudson, and T. Martin
Chest 116: 98S. [Full Text]  

Alveolar Epithelial Fluid Transport Can Be Upregulated Simultaneously in Rats by Two Different Mechanisms

Ybing Wang, Christian Jayr, Hans G. Folkesson, and Michael A. Matthay
Chest 116: 98S-100S. [Full Text]  

Hyperoxic Lung Injury Increases HOCl-Modified Lung Proteins and NA,K-Adenosine Triphosphatase Nitrotyrosine Content

David H. Ingbar, R. Bair, P. Jung, J. Heinecke, and I.Y. Haddad
Chest 116: 100S. [Full Text]  

Peroxynitrite Modulates Manganese-Containing Superoxide Dismutase Gene Expression in Lung Epithelial Cells

Robert M. Jackson, G. Parish, and E. Helton
Chest 116: 100S-101S. [Full Text]  

Hyperoxia Induces Thioredoxin and Thioredoxin Reductase Gene Expression in Lungs of Premature Baboons With Respiratory Distress and Bronchopulmonary Dysplasia

K. C. Das, X-L. Guo, and Carl W. White
Chest 116: 101S. [Full Text]  

Expression of Endothelial Nitric Oxide Synthase, Inducible Nitric Oxide Synthase, and Endothelin-1 in Lungs of Subjects Who Died With ARDS

K. H. Albertine, Z. M. Wang, and J. R. Michael
Chest 116: 101S-102S. [Full Text]  

Initiation and Tolerance to Acute Lung Injury: Yin-Yang Mechanisms Involving Interleukin-1

Rosa Faust-Chan, Brooks Hybertson, Sonia C. Flores, Richard M. Wright, and John E. Repine
Chest 116: 102S-103S. [Full Text]  

Chemokines in Lung Injury: Thomas A. Neff Lecture

Robert M. Strieter, Steven L. Kunkel, Michael P. Keane, and Theodore J. Standiford
Chest 116: 103S-110S. [Full Text]  

Macrophage Migration Inhibitory Factor and Acute Lung Injury

S.C. Donnelly, R. Bucala, C.N. Metz, I.S. Grant, C.R. Robertson, and C. Haslett
Chest 116: 111S. [Full Text]  

Functional Significance of CXCR2 Downregulation on Neutrophils From Patients With Severe Sepsis

R. Goodman, C. Cummings, C. Frevert, J. Quan, and T. Martin
Chest 116: 111S-112S. [Full Text]  

Cellular Alterations in Fibroproliferative Lung Disease

Galen B. Toews
Chest 116: 112S-116S. [Full Text]  

Levels of Evidence for the Pharmacologic Effectiveness of Prolonged Methylprednisolone Treatment in Unresolving ARDS

G. Umberto Meduri
Chest 116: 116S-118S. [Full Text]  

Fibrin Fragment Response Elements in the Plasminogen Activator Inhibitor Gene

M.A. Olman, J.S. Hagood, W.L. Simmons, and K.E. White
Chest 116: 118S-119S. [Full Text]  

Conference Summary: Acute Lung Injury

Michael A. Matthay
Chest 116: 119S-126S. [Full Text]  

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