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First published online on December 10, 2007
Chest, doi:10.1378/chest.07-2116
doi:10.1378/chest.07-2116
(Chest. 2008; 133:1101-1106)
© 2008 American College of Chest Physicians
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Right arrowRelated Editorial

Is Metalloproteinase-7 Specific for Idiopathic Pulmonary Fibrosis?*

Jin Won Huh, MD; Dong Soon Kim, MD; Yeon-Mok Oh, MD; Tae Sun Shim, MD; Chae Man Lim, MD; Sang Do Lee, MD; Yunsuck Koh, MD; Woo Sung Kim, MD; Won Dong Kim, MD and Kyu Rae Kim, MD

* From the Division of Pulmonary and Critical Care Medicine (Drs. Huh, D. S. Kim, Oh, Shim, Lim, Lee, Koh, W. S. Kim, and W. D. Kim) and Pathology (Dr. K. R. Kim), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Correspondence to: Dong Soon Kim, MD, Division of Pulmonary and Critical Care Medicine, Asan Medical Center, College of Medicine, University of Ulsan, 388-1, Poongnap-dong, Songpa-gu, Seoul, Korea; e-mail: dskim{at}amc.seoul.kr

Abstract

Background: Matrix metalloproteinase (MMP)-7 was reported to be a key molecule in the pathogenesis of idiopathic pulmonary fibrosis (IPF) based on the result of microarray analysis and knockout mice. However, the role of MMP-7 has not been determined in other types of idiopathic interstitial pneumonia (IIP). The aim of this study was to investigate the role of MMP-7 in IIP by comparing its expression in usual interstitial pneumonia (UIP) and cryptogenic organizing pneumonia (COP).

Methods: Levels of MMP and tissue inhibitors of metalloproteinase in BAL fluid and their expression on lung tissues were compared between normal control subjects (n = 5) and the patients with IPF (n = 6) and COP (n = 11).

Results: There was no significant difference in BAL fluid MMP-7 levels between UIP and COP, although it was higher in both diseases compared to normal control subjects. Furthermore, the pattern and the degree of MMP-7 expression in lung tissues were also similar in both IPF and COP, whereas MMP-2 level was higher in COP and MMP-9 level was higher in IPF.

Conclusion: MMP-7 seems to play an important role in the pathogenesis of not only IPF but also COP; therefore, it may not be the key factor determining the prognosis or reversibility of IIPs.

Key Words: BAL fluid • cryptogenic organizing pneumonia • idiopathic pulmonary fibrosis • immunohistochemistry • matrix metalloproteinase-7


Related Editorial

Matrix Metalloproteinase-7 Expression in Fibrosing Lung Disease: Restoring the Balance
Gregory P. Cosgrove and Roland M. du Bois
Chest 2008 133: 1058-1060. [Full Text] [PDF]



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G. P. Cosgrove and R. M. du Bois
Matrix Metalloproteinase-7 Expression in Fibrosing Lung Disease: Restoring the Balance
Chest, May 1, 2008; 133(5): 1058 - 1060.
[Full Text] [PDF]


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