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First published online on July 14, 2008
Chest, doi:10.1378/chest.08-0173
A more recent version of this article appeared on October 1, 2008
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Sleep Quality and Health-Related Quality of Life in Idiopathic Pulmonary Fibrosis

Vidya Krishnan, MD, MHS1; Meredith C. McCormack, MD, MHS2; Stephen C. Mathai, MD, MHS2; Shikhar Agarwal, MD3; Brittany Richardson4; Maureen R. Horton, MD2; Albert J. Polito, MD5; Nancy A. Collop, MD2 and Sonye K. Danoff, MD, PhD2

1MetroHealth Medical Center, Cleveland OH 2Johns Hopkins University School of Medicine, Baltimore, MD 3Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 4University of Maryland Baltimore County, Baltimore, MD 5Mercy Medical Center, Baltimore, MD

sdanoff{at}jhmi.edu

Abstract

BackgroundIdiopathic pulmonary fibrosis (IPF) is a progressive disorder resulting in irreversible scarring of the lung parenchyma. Although fatigue is a prominent symptom for patients with IPF, little is known about sleep quality in patients with IPF.

MethodsIn this cross-sectional study of 41 patients with IPF from a prospectively designed cohort, we ascertained sleep quality by means of the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale. Health status, baseline demographics and physiologic parameters were also assessed.

ResultsPatients with IPF reported extremely poor sleep quality and high frequency of daytime sleepiness, which differs significantly from normal control populations. Further, poor sleep quality was not associated with body-mass index, age, gender or lung function. This population also demonstrated extremely poor health status in a number of domains, including physical function and vitality. Poor sleep quality (by the global Pittsburgh Sleep Quality Index) was significantly associated with decreased quality of life in several domains, including role of physical function (r=–0.58, p=0.001), vitality (r=–0.43, p=0.015) and role of emotions (r=–0.40, p=0.023).

ConclusionsPoor sleep quality is extremely common in patients with IPF and is not predicted by variables traditionally associated with sleep disordered breathing. Further, poor sleep quality is associated with poor quality of life. These findings suggest that systematic evaluation of the cause of poor sleep quality in IPF is merited.

Key Words: sleep quality • interstitial lung disease • quality of life • Epworth sleepiness scale • Pittsburgh Sleep Quality Index






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