HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:
Guest Access | Sign In via User Name/Password

This Article Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Personal Article Archive Download to citation manager Google Scholar Articles by Nakajima, K. Articles by Munakata, H. PubMed PubMed Citation Articles by Nakajima, K. Articles by Munakata, H.

A Possible Association between Suspected Restrictive Pattern as Assessed by Ordinary Pulmonary Function Test and The Metabolic Syndrome

¹Department of Medical Dietetics, Faculty of Pharmaceutical Sciences, Josai University ²Department of Internal Medicine, Social Insurance Omiya General Hospital

keinaka{at}josai.ac.jp

Abstract

BackgroundImpaired restrictive pulmonary function has been reported to be associated with insulin resistance and metabolic abnormalities. However, a possible association of restrictive pulmonary defect with metabolic syndrome (MetS) is not well understood. We examined the association in comparison with C-reactive protein (CRP), a predictor for MetS.

MethodsWe recruited 2,396 apparently healthy adults and investigated associations between pulmonary function, metabolic abnormality, and MetS defined by three different criteria. Abnormal pulmonary function was evaluated by both continuous pulmonary function variables including percentage of predicted forced vital capacity (%PFVC) and clinical category defined according to the ATS/ERS guidelines.

ResultsCRP and %PFVC, but not ratio of forced expiratory volume in 1 second to FVC (FEV₁/FVC), were significantly correlated with metabolic abnormalities even after adjustment for confounders including waist circumference. After adjustment for age, sex, and height, the odds ratios (ORs) of restrictive pattern (RP) as defined by reduced FVC and normal FEV₁/FVC using lower limit of normal and RP substitutively defined by reduced FVC and FEV₁/FVC 85% for MetS were 1.76 to 2.52 (P <0.05 to <0.0001) and 1.87 to 2.28 (P <0.05 to <0.01), respectively. The obstructive pattern (OP) was not significantly associated with any MetS criteria. Moderate-to-severe RP, but not high CRP (>3.0 mg/L), was consistently associated with the three MetS criteria (OR, 2.08 to 3.57, P <0.05 to <0.01), even after adjustment for confounders.

ConclusionImpaired restrictive pulmonary function, but not OP, might be associated with metabolic disorders and MetS in a severity-dependent manner.

Key Words: pulmonary function • restrictive pattern • metabolic syndrome • C-reactive protein