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Chest, Vol 82, 526-529, Copyright © 1982 by American College of Chest Physicians

ARTICLES

Reversible alterations in immunoregulatory T cells in smoking. Analysis by monoclonal antibodies and flow cytometry

LG Miller, G Goldstein, M Murphy and LC Ginns

We characterized T-lymphocyte subsets in peripheral blood of smokers (N = 60) and nonsmokers (N = 35). Total T-lymphocytes and T cell subsets were similar to nonsmokers in light and moderate smokers. In heavy smokers, total OKT3+ cells were increased, the percentage of OKT4+ cells was decreased, and percentage and total number of OKT8+ cells were increased. The ratio of OKT4+ to OKT8+ lymphocytes was decreased in heavy smokers. The percentage of OKT8+ cells and the OKT4+/OKT8+ ratio returned to normal in heavy smokers six weeks after they stopped smoking. These findings suggest that cigarette smoking causes reversible alterations in immunoregulatory T cells.


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