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Chest, Vol 80, 896-898, Copyright © 1981 by American College of Chest Physicians

ARTICLES

Mucociliary transport and ultrastructural abnormalities in Polynesian bronchiectasis

DA Waite, SJ Wakefield, JB Mackay and IT Ross

Ciliated bronchial or nasal epithelium from 20 Polynesian bronchiectatic patients was examined in an electron microscope. In all patients there was a partial or complete loss of dynein arms. Also, in many patients other ciliary abnormalities were present with a high proportion, often over 25%, of cilia affected. This contrasts with a control group where ciliary abnormalities were infrequent. Mucociliary clearance, measured by imaging 99mTc sulfide dust with a gamma camera, was either absent or markedly reduced in these bronchiectatic patients.


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[Abstract] [Full Text] [PDF]


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Copyright © 1981 by the American College of Chest Physicians.