Chest
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Godard, P
Right arrow Articles by Michel, F.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Godard, P
Right arrow Articles by Michel, F.

Chest, Vol 80, 447-452, Copyright © 1981 by American College of Chest Physicians

ARTICLES

Lymphocyte subpopulations in bronchoalveolar lavages of patients with sarcoidosis and hypersensitivity pneumonitis

P Godard, J Clot, O Jonquet, J Bousquet and FB Michel

Sarcoidosis and hypersensitivity pneumonitis (HP) are two granulomatous pulmonary diseases, the former of unknown cause and the latter with known etiology. To compare these diseases, we practiced bronchoalveolar lavage on 16 patients with sarcoidosis, 6 with HP, 10 healthy nonsmokers, and 10 smokers with chronic bronchitis. Lymphocyte subpopulations were evaluated by four membrane markers: (1) The total cell count was very high in patients with HP compared with those with sarcoidosis and with healthy subjects. (2) The proportion of lymphocytes was higher in patients with HP than in those with sarcoidosis (P less than 0.02) and also higher in patients with sarcoidosis than in healthy subjects (P less than 0.001). (3) There were only a small number of B cells and of Fc-receptor bearing cells. (4) The lymphocytes identified by our techniques were mainly T cells in sarcoidosis and HP (68.4 +/- 3.5 percent and 76.8 +/- 3.6 percent, respectively), but the proportion of "active" E-rosette-forming cells was higher in sarcoidosis than in HP (28.1 +/- 2.5 percent vs 9.8 +/- 1.5 percent) and higher in patients with HP than in healthy subjects. These studies suggest that: (1) these two granulomatoses may be differentiated by this method, which might also be used for other pulmonary angiitis and granulomas; (2) cell-mediated immune phenomena play a major role in the pathogenesis of sarcoidosis, and conversely the finding of low active E-rosette proportions in HP limits the role of delayed-type hypersensitivity; and (3) the exact role of immunologic activation of bronchopulmonary macrophages, "presenting" antigen to T cells, for instance, must be evaluated.


This article has been cited by other articles:


Home page
 ThoraxHome page
C Chavis, I Vachier, P Godard, J Bousquet, and P Chanez
Lipoxins and other arachidonate derived mediators in bronchial asthma
Thorax, October 1, 2000; 55(90002): 38S - 41.
[Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Schenker
Respiratory Health Hazards in Agriculture
Am. J. Respir. Crit. Care Med., November 1, 1998; 158(2007): S1 - S76.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1981 by the American College of Chest Physicians.