Chest, Vol 80, 392-398, Copyright © 1981 by American College of Chest Physicians

ARTICLES

Exercise conditioning and cardiopulmonary fitness in cystic fibrosis. The effects of a three-month supervised running program

DM Orenstein, BA Franklin, CF Doershuk, HK Hellerstein, KJ Germann, JG Horowitz and RC Stern

Exercise intolerance is common in cystic fibrosis (CF). We examined the effects of a supervised three-month running program on exercise tolerance, pulmonary function, cardiorespiratory fitness (peak oxygen consumption), and respiratory muscle endurance in CF patients. We studied 31 patients, 21 exercise and ten control, aged 10 to 30 years, with pulmonary involvement ranging from mild to severe. The exercise and control groups were not significantly different with respect to age, sex, pulmonary function, exercise tolerance, or cardiorespiratory fitness. After three months of physical conditioning, the exercise group had significantly increased exercise tolerance and peak oxygen consumption and significantly lower heart rates for submaximal work loads, while the nonexercising (control) group was unchanged in all these variables. The FEV1 decreased significantly in the control group. There were no other significant changes in pulmonary function in either the control or exercise group. Respiratory muscle endurance increased significantly in the exercise patients, and did not change in the control patients. There were no adverse effects of the program. The data suggest that a supervised running program can increase CF patients' exercise tolerance and cardiorespiratory fitness, perhaps in part by increasing respiratory muscle tolerance. The effects of a much longer program deserve study.

This article has been cited by other articles:

				W. D. Reid, E. L. Geddes, K. O'Brien, D. Brooks, and J. Crowe Effects of inspiratory muscle training in cystic fibrosis: a systematic review Clinical Rehabilitation, October 1, 2008; 22(10-11): 1003 - 1013. [Abstract] [PDF]

				M. Decramer and R. Gosselink Physical activity in patients with cystic fibrosis: a new variable in the health-status equation unravelled? Eur. Respir. J., October 1, 2006; 28(4): 678 - 679. [Full Text] [PDF]

				H. Hebestreit, S. Kieser, S. Rudiger, T. Schenk, S. Junge, A. Hebestreit, M. Ballmann, H-G. Posselt, and S. Kriemler Physical activity is independently related to aerobic capacity in cystic fibrosis Eur. Respir. J., October 1, 2006; 28(4): 734 - 739. [Abstract] [Full Text] [PDF]

				C Newall, R A Stockley, and S L Hill Exercise training and inspiratory muscle training in patients with bronchiectasis Thorax, November 1, 2005; 60(11): 943 - 948. [Abstract] [Full Text] [PDF]

				M E Dodd and S A Prasad Physiotherapy management of cystic fibrosis Chronic Respiratory Disease, July 1, 2005; 2(3): 139 - 149. [Abstract] [PDF]

				A J Moorcroft, M E Dodd, J Morris, and A K Webb Individualised unsupervised exercise training in adults with cystic fibrosis: a 1 year randomised controlled trial Thorax, December 1, 2004; 59(12): 1074 - 1080. [Abstract] [Full Text] [PDF]

				D. M. Orenstein, M. F. Hovell, M. Mulvihill, K. K. Keating, C. R. Hofstetter, S. Kelsey, K. Morris, and P. A. Nixon Strength vs Aerobic Training in Children With Cystic Fibrosis: A Randomized Controlled Trial Chest, October 1, 2004; 126(4): 1204 - 1214. [Abstract] [Full Text] [PDF]

				P. H. C. Klijn, A. Oudshoorn, C. K. van der Ent, J. van der Net, J. L. Kimpen, and P. J. M. Helders Effects of Anaerobic Training in Children With Cystic Fibrosis: A Randomized Controlled Study Chest, April 1, 2004; 125(4): 1299 - 1305. [Abstract] [Full Text] [PDF]

				P. H. C. Klijn, J. van der Net, J. L. Kimpen, P. J. M. Helders, and C. K. van der Ent Longitudinal Determinants of Peak Aerobic Performance in Children With Cystic Fibrosis Chest, December 1, 2003; 124(6): 2215 - 2219. [Abstract] [Full Text] [PDF]

				W. P. Sexauer, H.-K. Cheng, and S. B. Fiel Utility of the Breathing Reserve Index at the Anaerobic Threshold in Determining Ventilatory-Limited Exercise in Adult Cystic Fibrosis Patients Chest, October 1, 2003; 124(4): 1469 - 1475. [Abstract] [Full Text] [PDF]

				A. G. Thin, S. J. Linnane, E. F. McKone, R. Freaney, M. X. FitzGerald, C. G. Gallagher, and P. McLoughlin Use of the Gas Exchange Threshold to Noninvasively Determine the Lactate Threshold in Patients With Cystic Fibrosis* Chest, June 1, 2002; 121(6): 1761 - 1770. [Abstract] [Full Text] [PDF]

				H. Blau, H. Mussaffi-Georgy, G. Fink, C. Kaye, A. Szeinberg, S. A. Spitzer, and J. Yahav Effects of an Intensive 4-Week Summer Camp on Cystic Fibrosis* : Pulmonary Function, Exercise Tolerance, and Nutrition Chest, April 1, 2002; 121(4): 1117 - 1122. [Abstract] [Full Text] [PDF]

				J. Navarro, M. Rainisio, H.K. Harms, M.E. Hodson, C. Koch, G. Mastella, B. Strandvik, and S.G. McKenzie Factors associated with poor pulmonary function: cross-sectional analysis of data from the ERCF Eur. Respir. J., August 1, 2001; 18(2): 298 - 305. [Abstract] [Full Text] [PDF]

				A. HEBESTREIT, U. KERSTING, B. BASLER, R. JESCHKE, and H. HEBESTREIT Exercise Inhibits Epithelial Sodium Channels in Patients with Cystic Fibrosis Am. J. Respir. Crit. Care Med., August 1, 2001; 164(3): 443 - 446. [Abstract] [Full Text] [PDF]

				Pulmonary Rehabilitation---1999 Am. J. Respir. Crit. Care Med., May 1, 1999; 159(5): 1666 - 1682. [Full Text] [PDF]

				K. de MEER, V. A. M. GULMANS, and J. van der LAAG Peripheral Muscle Weakness and Exercise Capacity in Children with Cystic Fibrosis Am. J. Respir. Crit. Care Med., March 1, 1999; 159(3): 748 - 754. [Abstract] [Full Text]

				A. R. SHAH, D. GOZAL, and T. G. KEENS Determinants of Aerobic and Anaerobic Exercise Performance in Cystic Fibrosis Am. J. Respir. Crit. Care Med., April 1, 1998; 157(4): 1145 - 1150. [Abstract] [Full Text] [PDF]

				D. E. O'DONNELL, M. MCGUIRE, L. SAMIS, and K. A. WEBB General Exercise Training Improves Ventilatory and Peripheral Muscle Strength and Endurance in Chronic Airflow Limitation Am. J. Respir. Crit. Care Med., May 1, 1997; 157(5): 1489 - 1497. [Abstract] [Full Text]