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Chest, Vol 80, 23-30, Copyright © 1981 by American College of Chest Physicians

ARTICLES

The maximum expiratory flow-volume curve with air and a low-density gas misture. An analysis of subject and observer variability

N Berend, NA Nelson, J Rutland, GE Marlin and AJ Woolcock

The subject and intra- and inter-observer variability of three measurements derived from the maximal expiratory flow-volume (MEFV) curve with air and helium-oxygen (HeO2) mixture was determined in ten normal subjects who produced curves in the morning and afternoon of three consecutive days and again on one day a month later. The measurements examined were the maximum flow at 50% vital capacity (V50), the percentage increases in V50 when breathing the He-O2 mixture (delta V50), and the volume at which the curves on air and He-O2 first meet or intersect (VisoV). The delta V50 and VisoV were shown to have a greater degree of variability than the V50 and, in the case of VisoV, this was contributed to significantly by the observer variability. The within-subject variability of the delta V50 and VisoV was so great that the usefulness of these tests in following changes in lung function of individual patients must be questioned.


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Copyright © 1981 by the American College of Chest Physicians.