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Chest, Vol 79, 552-554, Copyright © 1981 by American College of Chest Physicians

ARTICLES

Hemodynamic effects of rapid bolus hypertonic sodium bicarbonate

JS Huseby and DG Gumprecht

We found that rapid bolus administration of hypertonic sodium bicarbonate in the recommended clinical dose produced significant, though transient, increases in intracranial pressure and decreases in blood pressure in dogs. These effects, which are related to the high osmolarity of the drug (2,000 mOsm/L), are not found when it is administered slowly.


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Copyright © 1981 by the American College of Chest Physicians.