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(Chest. 1981;79:53S-55S.)
© 1981 American College of Chest Physicians

Cotton Dust and Complement in Vivo

Stephen A. Olenchock Ph.D.1; Judith C. Mull M.S.1; Brian A. Boehlecke M.D.1; and Pervis C. Major Ph.D.1

1 From the Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia

Cotton grown in Stoneville, Mississippi and harvested by three different methods was examined for anticomplementary activity in human serum in vivo. Subjects exposed to cotton dust in a model cardroom for six hours showed changes in C3c and CH50 after exposure to closed boll harvested, bract removed cotton dust when compared with a group of normal, unexposed controls. Decreases in C3c, C4, and C3A were associated with decreases in FEV1 after exposure to closed boll harvested bract intact cotton dust. The data from this preliminary study suggest in vivo associations between inhalation of cotton dusts and complement which appear to be independent of endotoxin contamination. These findings suggest a relationship between cotton dust inhalation and complement-mediated respiratory impairment.






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Copyright © 1981 by the American College of Chest Physicians.