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Chest, Vol 78, 880-882, Copyright © 1980 by American College of Chest Physicians

ARTICLES

Late, late doxorubicin cardiotoxicity

SL Gottlieb, WA Edmiston Jr and LJ Haywood

Cardiac toxicity is a major complication which limits the use of adriamycin as a chemotherapeutic agent. Cardiomyopathy is frequent when the total dose exceeds 600 mg/m2 and occurs within one to six months after cessation of therapy. A patient is reported who developed progressive cardiomyopathy two and one-half years after receiving 580 mg/m2 which apparently represents late, late cardiotoxicity.


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J. J. Doyle, A. I. Neugut, J. S. Jacobson, V. R. Grann, and D. L. Hershman
Chemotherapy and Cardiotoxicity in Older Breast Cancer Patients: A Population-Based Study
J. Clin. Oncol., December 1, 2005; 23(34): 8597 - 8605.
[Abstract] [Full Text] [PDF]


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