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Chest, Vol 78, 791-795, Copyright © 1980 by American College of Chest Physicians

ARTICLES

Histoplasma capsulatum endocarditis cured by amphotericin B combined with surgery

RW Bradsher, CG Wickre, AM Savage, WE Harston and RH Alford

A patient is reported who had Histoplasma capsulatum endocarditis, a rare form of disseminated histoplasmosis. He also had disseminated intravascular coagulopathy and defects in cell-mediated immune responses to Histoplasma antigens. Prompt etiologic diagnosis was made by stain of tissue from a mouth ulcer and confirmed by culture of the organism from blood. An echocardiogram compared to a previous normal echocardiogram indicated changes consistent with a vegetation. Histologic examination of the resected valve demonstrated organisms. Amphotericin B administration (3.4 g) plus an aortic valve replacement resulted in cure.




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Copyright © 1980 by the American College of Chest Physicians.