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Chest, Vol 78, 654-656, Copyright © 1980 by American College of Chest Physicians

ARTICLES

Toxic synergism of disopyramide and hyperkalemia

BD Maddux and RB Whiting

A patient is presented whose electrocardiogram became remarkably abnormal and who developed hypotension while receiving disopyramide and potassium. This report documents a potassium-disopyramide synergism leading to life-threatening toxicity. These abnormalities were corrected by glucose, insulin and bicarbonate therapy, suggesting that serious disopyramide toxicity may be enhanced by hyperkalemia and reversed by lowering the serum potassium.




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Copyright © 1980 by the American College of Chest Physicians.