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Chest, Vol 78, 304-305, Copyright © 1980 by American College of Chest Physicians

ARTICLES

Tissue levels of doxycycline in the human lung and pleura

H Thadepalli, AK Mandal, VT Bach and SS Oparah

Antibiotic concentrations in the human lung and pleural tissue were measured following intravenous administration of doxycycline. The average serum levels were 9.3, 7.0 and 3.0 micrograms/ml at 1, 2, and 3 hours; correspondingly, the lung tissue levels were 6.8, 3.5 and 2.3 micrograms/g. The pleural tissue antibiotic concentrations at the same time intervals were 2.5, 1.5, and 1.5 micrograms/g. This suggests that doxycycline is retained well by the lung and the pleura, well above the minimal inhibitory concentration of most of the common bacterial pathogens of the lung, and may be used in the treatment of lung infections caused by susceptible organisms.




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Copyright © 1980 by the American College of Chest Physicians.