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Chest, Vol 77, 142-146, Copyright © 1980 by American College of Chest Physicians

ARTICLES

Changes in blood P50. Effects on oxygen delivery when arterial hypoxemia is due to shunting

L Rossoff, R Zeldin, E Hew and A Aberman

The theoretic effect of increased values for the oxygen pressure at an oxygen saturation of 50 percent on oxygen delivery in arterial hypoxemia due to right-to-left shunting was analyzed using a mathematical model of the oxygen-hemoglobin equilibrium curve. We found that, regardless of the size of the shunt, a rightward shift of the curve resulted in increased mixed venous oxygen tension, increased arterial oxygen pressure, and, hence, a decreased alveolar-arterial oxygen pressure difference compared to the standard curve (hemoglobin level, cardiac output, and oxygen consumption remaining constant).




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Copyright © 1980 by the American College of Chest Physicians.