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(Chest. 1973;64:16-20.)
© 1973 American College of Chest Physicians

Immune Globulin Characterization of Complement Fixing Antibodies in Histoplasmic Infection

Gerald L. Baum M.D., F.C.C.P.1; Thomas M. Daniel M.D., F.C.C.P.1; and Emily H. Rice B.S.1

1 Mycology Research Laboratory, Veterans Administration Hospital, and the Department of Medicine, Case Western Reserve Universitv School of Medicine, Cleveland

Complement fixing antibody activity against mycelial phase and yeast phase antigen of H capsulatum has been studied in immune globulin fractions of serum from 13 patients with proved histoplasmosis. Immune globulin G (IgG) specific complement fixing activity was predominant in the human serum regardless of which antigen was used in both acute and nonacute cases. Immune globulin M (IgM) activity was noted in the three cases of primary histoplasmosis, the two epidemic cases and in two of three disseminated cases. No IgM activity was noted in three of five chronic cases. It appears as if infection with Histoplasma capsulatum elicits an immune globulin response in humans which qualitatively is similar to that seen in acute and chronic brucellosis and acute and recrudescent typhus.

Submitted on January 15, 1973
Accepted on February 9, 1973






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Copyright © 1973 by the American College of Chest Physicians.