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(Chest. 1973;63:943-947.)
© 1973 American College of Chest Physicians

Cardiac Effects of Two Cocktails in Normal Man

Lawrence Gould M.D., F.C.C.P.1; C. V. Ramana Reddy M.B.B.S.1; Kumar Goswami M.B.B.S.1; Kalyanasundaram Venkataraman M.D.1; and Robert F. Gomprecht M.D.1

1 Department of Medicine, Misericordia-Fordham Hospitals, Bronx, New York, and New York Medical College

Ten normal subjects ingested four ounces of Canadian whiskey. Systolic time intervals were obtained before and for one hour after alcohol intake. Maximum changes were seen 60 minutes after alcohol ingestion. At this time, left ventricular depression was manifested by a significant increase in the pre-ejection period, isometric contraction time and the PEP/LVET ratio. The left ventricular ejection time showed no significant change, while the cardiac rate fell significantly. The ingestion of isocaloric glucose as a control produced no alterations in the systolic time intervals. Thus, four ounces of whiskey can impair cardiac function in normal subjects.




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R. Paz, R. Jortner, P. A. Tunick, S. Sclarovsky, B. Eilat, J. L. Perez, and I. Kronzon
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