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Novel Nonantibiotic Therapies for Pneumonia^*

Cytokines and Host Defense

^* From the Louisiana State University Health Sciences Center, Department of Medicine, Section of Pulmonary/Critical Care Medicine, New Orleans, LA.

Correspondence to: Steve Nelson, MD, FCCP, Louisiana State University Health Sciences Center, Department of Medicine, Section of Pulmonary/Critical Care Medicine, 1901 Perdido St, Suite 3205, New Orleans, LA 70112; e-mail: snelso1{at}lsuhsc.edu

Effective host defense against bacterial infection is dependent on the activation and recruitment of phagocytic cells. The initiation, maintenance, and resolution of this inflammatory response in the setting of bacterial pneumonia is dependent on the expression of cytokines. As the complexities of the host-pathogen interaction are further dissected and unraveled, immunologic manipulation of cytokine expression will likely become an important adjuvant therapy in the treatment of serious lung infections.

Key Words: cytokines • granulocyte colony-stimulating factor • inflammatory response • interleukins • pneumonia • tumor necrosis factor

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