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From the Department of Medicine, University of Barcelona, Barcelona, Spain.
Correspondence to: Roberto Rodriguez-Roisin, MD, Chief of Service, Servei de Pneumologia: Allergia Respiratòria, Hospital Clinic, Villarroel 170, Barcelona 08036, Spain; e-mail: roisin{at}medicina.ub.es
In patients with COPD, an acute worsening of respiratory symptoms is often described as an exacerbation. Exacerbations are associated with a significant increase in mortality, hospitalization, and health-care utilization, but there is currently no widely accepted definition of what constitutes an exacerbation of COPD. This paper summarizes the discussions of the workshop, "COPD: Working Towards a Greater Understanding," in which the participants proposed the following working definition of an exacerbation of COPD: a sustained worsening of the patient’s condition, from the stable state and beyond normal day-to-day variations, that is acute in onset and necessitates a change in regular medication in a patient with underlying COPD.
Key Words: COPD • definition • exacerbation
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