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(Chest. 1995;107:261S-266S.)
© 1995 American College of Chest Physicians

Dose-Intensive Therapy for Small Cell Lung Cancer

Anthony D. Elias MD1

1 From the Dana-Farber Cancer Institute and the Harvard Medical School, Boston

Enhancement of dose and dose intensity increases tumor response and may enhance long-term progressionfree survival in patients with small cell lung cancer. Several strategies are identified to intensify therapy safely: a traditional induction/intensification mode, in which high-dose therapy with hematopoietic stem cell support is used to treat patients responding to conventional-dose therapy; and multicycle dose-intensive approaches, in which higher-dose therapy is administered over multiple cycles at initiation of therapy. This paper reviews some of the recently completed and activated trials (particularly those developed at the Dana-Farber Cancer Institute) exploring these concepts.






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Copyright © 1995 by the American College of Chest Physicians.