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(Chest. 1994;105:63S-66S.)
© 1994 American College of Chest Physicians

Amplitude-modulated Ventilation

Effects in Acute Lung Injury and Characterization of Mechanisms of Action

Edward P. Ingenito M.D., Ph.D.1 and Maryellen Kennedy M.D.2

1 The Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital
2 Department of Anesthesia, Children's Hospital Medical Center, and Harvard Medical School, Boston.

Amplitude modulated ventilation, administered as intermittent deep breaths to guinea pigs with experimental ALl, resulted in an increase in lung compliance which lasted many respiratory cycles. The response was greater in magnitude and longer lasting than that observed in control animals. Viscoelastic dynamic responses of parenchymal tissue strips and surfactant film preparations from damaged and control animals used in a microstructural model of alveolar stability failed to adequately predict the time responses observed in the intact lung. We are currently developing a more detailed dynamic model of alveolar microstructure which we hope will allow us to better understand how AMV may work, and how we can plan rationale strategies for improving alveolar stability and overall lung function in ALI without promoting damage in previously intact regions of the lung.






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Copyright © 1994 by the American College of Chest Physicians.